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Peak 15 Bio
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Regenerative medicine to rebuild the brain's infrastructure

Off-the-shelf cell therapies designed to restore the injured neurovascular environment

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News €10.7M Disruptive Technologies Innovation Fund award supports the Can‑Vas 001 programme for neonatal HIE. Read more →

Technology

Diseases of the developing brain are prime indications for regenerative medicine

Endothelial colony-forming cells (ECFCs) are the body's natural blood-vessel builders — rare cells that form and repair the vessels every organ depends on.

In the brain, those vessels feed and protect neurons, and their signals help injured tissue recover.

Can‑Vas is an allogeneic platform of ECFCs and mesenchymal stromal cells (MSCs). The starting point comes from healthy placentas donated after full-term births — tissue that would otherwise be discarded. Can‑Vas generates cryopreserved off-the-shelf products ready at the point of care with no wait for a matched donor.

How Can‑Vas works
Placental ECFCs under immunofluorescence — endothelial markers in green, nuclei in blue
Placental ECFCs · immunofluorescence
27×
more ECFCs from placenta than other sources

Mechanism

Restoring the neurovascular environment

Can‑Vas cells act through paracrine support — signalling to the injured microenvironment — to help the brain rebuild that infrastructure itself.

01Deliver

Reach the injury early

Cryopreserved cells are thawed and administered within the critical window, using minimally invasive routes suited to each patient — including intranasal delivery for the newborn.

02Signal

Support the environment

ECFCs and MSCs release paracrine factors that act on the injured neurovascular environment, moderating the hostile post-injury environment.

03Outcome

Protect and Rebuild

In large-animal models of perinatal brain injury, treatment preserved blood–brain-barrier integrity and protected neurons.

Pipeline

A wholly-owned pipeline of allogeneic cell therapies

Peak 15 Bio is developing allogeneic, off-the-shelf cell therapies for serious neurological diseases where a treatment window exists and no adequate therapy does — from rare conditions of the newborn brain to adult neurological disease.

Scientist pipetting samples in a laboratory
ProgrammeIndicationApproachStage
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DiscoveryPreclinicalIND-enablingPhase 1/2

All Can‑Vas programmes are investigational.

About

About Peak 15 Bio

Peak 15 Bio exists to create medicines for serious diseases where treatment options are limited or absent. Our science begins where life does — with the newborn brain — and is built to scale to neurological disease across the lifespan.

Meet the team

Partner with us

We work with investors, clinicians, industry and patient communities who share our conviction that the earliest injuries deserve the most ambitious medicine.

General & partnering: info@peak15bio.com
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